IGFBP2 Produces Rapid-Acting and Long-Lasting Effects in Rat Models of Posttraumatic Stress Disorder via a Novel Mechanism Associated with Structural Plasticity
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منابع مشابه
IGFBP2 Produces Rapid-Acting and Long-Lasting Effects in Rat Models of Posttraumatic Stress Disorder via a Novel Mechanism Associated with Structural Plasticity
Background Posttraumatic stress disorder is an anxiety disorder characterized by deficits in the extinction of aversive memories. Insulin-like growth factor 1 (IGF1) is the only growth factor that has shown anxiolytic and antidepressant properties in human clinical trials. In animal studies, insulin-like growth factor binding protein 2 (IGFBP2) shows both IGF1-dependent and IGF1-independent pha...
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متن کاملTitle : Rapid and Long - lasting Plasticity of Input - Output Mapping
230 words, Text: 3219 words, Figures: 3 * To whom correspondence should be addressed: Dr. Peter L. Strick Dept. of Neurobiology University of Pittsburgh School of Medicine 4074 Biomedical Science Tower-3 3501 Fifth Avenue Pittsburgh, PA 15261, USA E-mail: [email protected] Tel: 412-383-9961 Fax: 412-383-9061 Page 1 of 25 Articles in PresS. J Neurophysiol (August 23, 2006). doi:10.1152/jn.00209.2...
متن کاملRapid and long-lasting plasticity of input-output mapping.
Skilled use of tools requires us to learn an "input-output map" for the device, i.e., how our movements relate to the actions of the device. We used the paradigm of visuo-motor rotation to examine two questions about the plasticity of input-output maps: 1) does extensive practice on one mapping make it difficult to modify and/or to form a new input-output map and 2) once a map has been modified...
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ژورنال
عنوان ژورنال: International Journal of Neuropsychopharmacology
سال: 2017
ISSN: 1461-1457,1469-5111
DOI: 10.1093/ijnp/pyx007